(Image source: Marvel Studios)
Details surrounding the villains set to appear in "Spider-Man 4: Brand New Day" have remained largely under wraps. While Scorpion and Tombstone are reportedly confirmed, they are not considered high-profile antagonists, suggesting they won't be central to the plot. However, it appears they are just two of many lesser-known villains expected to feature, potentially making this the largest ensemble of antagonists in any "Spider-Man" film to date.

(Image source: Marvel Studios)
According to Alex Perez, a prominent Marvel Cinematic Universe scooper writing for The Cosmic Circus, "Brand New Day" will feature as many as nine villains. Perez emphasized that most of these characters are considered B- or C-list in the comics. Perez also revealed that Marvel Studios is keen on seeing Deadpool and the supervillain Mephisto interact with Spider-Man in future storylines. However, the primary hurdle remains Sony Pictures' complex licensing agreement, as Spider-Man is not fully under Marvel's control like other MCU characters.
via: The Cosmic Circus