With the release of the first trailer for "Spider-Man: Brand New Day," the Marvel Cinematic Universe's new direction for Peter Parker's future is beginning to emerge. One of the most intriguing changes is the absence of the classic character The Lizard on Earth-616, with Bruce Banner, the Hulk, instead stepping into the pivotal scientific support role previously held by Curt Connors in Spider-Man's life. 
In the original comics and animated series, Dr. Connors served not only as a scientific consultant but also as one of the few people Peter could truly trust. While "Spider-Man: No Way Home" briefly featured The Lizard from "The Amazing Spider-Man" universe, the character never truly integrated into the main MCU. "Brand New Day"'s decision to have Banner assume this position signals Peter's official entry into a more isolated phase, distinct from his past "Avengers era."
The trailer reveals Peter actively seeking Banner's assistance to understand the source of his abnormal powers. This setup echoes a classic Silver Age comic storyline where Spider-Man mutated, growing four extra arms, and ultimately relied on Connors' help to revert. This time, however, the crisis appears far more dangerous and uncontrollable.
In the film's trailer, Bruce Banner gravely warns Peter, "If genetic mutation occurs, it will be extremely dangerous." He further mentions that "spiders have three life cycles, and become extremely vulnerable during transition." This new piece of lore not only intensifies the sense of crisis surrounding Peter's unstable powers but also hints that he is undergoing a transformative stage, teetering on the brink of collapse.
This portrayal echoes a plotline from the 1990s "Spider-Man: The Animated Series," where Peter sought Connors' help to test for genetic abnormalities. However, the current predicament appears far more advanced, potentially involving deeper genetic recombination and even leading to extreme mutated forms akin to "Man-Spider." If this speculation holds true, Peter faces not just a loss of control, but a crisis that could fundamentally alter his very existence.
On another note, Bruce Banner's presence extends beyond mere scientific support; his dual identity with the Hulk creates a clever narrative parallel with The Lizard. Just as Connors long struggled between his humanity and monstrous instincts, Banner similarly carries the shadow of uncontrolled transformation. This "scientist and monster coexisting" characteristic makes him the most compelling candidate to replace The Lizard.
Observing this trailer, "Spider-Man: Brand New Day" appears to be more than just a new beginning; it seems to pull Spider-Man back to a narrative core of "individual crisis." Without the support of a hero team, Peter must confront the risk of his own genetics and identity unraveling. Bruce Banner emerges as his sole rational anchor—and perhaps the most likely person to witness his eventual loss of control.
via： Screen Rant